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Trials designed to inform clinical practice in the real world are referred to as pragmatic trials. They are often described by their focus on practical aspects of designing a study, including the recruitment and consent process, as well as adherence and the use of routinely available equipment.
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Another example of a trial that is pragmatic is the Home Blood Pressure Management (HBPM) study, which used various investigators and included participants from various geographical areas. This type of heterogeneity is required for pragmatic trials to be valid and also helps to reduce the chance of bias in the results. However, too much heterogeneity, can cause problems with the trial design.
Pragmatic Play Pragmatic Play, one of the biggest players on the live casino market, offers various classic table games such as Blackjack and Roulette. The live studios of the company in Romania and Malta offer customers an authentic gambling experience, and a wide selection of virtual betting options. The company also hosts a variety of games which make online gambling fun and interactive. Some of these shows feature a live host, while others are hosted by celebrities from the industry.
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Legality
Pragmatic Play has earned a name for itself by providing high-quality games and a superior user experience. Its software can be used on mobile devices as well as in various languages. It has earned itself the status of one of the leading gaming platforms for casinos despite its relatively young age. Its latest releases include Wolves, a 5-reel video slot that has a healthy RTP and stunning graphics. Its other notable titles are Wolf Gold and Chilli Heat.
Pragmatic trials are designed to replicate real-life settings and achieve maximum external validity. They are usually commissioned by practitioners and policy makers to guide their decision-making. They can also be used to assess the causality of an intervention and its effects. They should, however, not, be used to replace explanatory studies.

The pragmatism idea is controversial and there are doubts about whether pragmatic trials can replace tests for explanations or if they are an alternative to them. Schwartz and Lellouch1 suggested the distinction between explanatory trials, which validate the clinical or physiological hypothesis as well as pragmatic trials that inform policy and practice decisions. They also suggested a framework dubbed PRECIS for pragmatic trials.2 This tool tried to define the elements of a pragmatic study, including recruitment, design, delivery of the intervention, and follow-up.
The number of pragmatic trials is growing. A recent Medline query that used the words naturalistic and pragmatic, restricted to randomised controlled trials (RCTs), returned 34 articles. These are highlighted in red on Figure 2. This suggests that the health sciences community is becoming more aware of the importance of pragmatic thinking. It is important to note that the majority of these studies were conducted in primary care settings.